The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Red cell cholesterol enrichment and spur cell anemia in dogs fed a cholesterol-enriched atherogenic diet.

A diet supplemented with cholesterol and coconut oil is atherogenic in dogs. The purpose of the present study was to examine the effects of this diet on red cells in pure-bred beagles and greyhounds. Within 3 days after the initiation of this diet red cell cholesterol/phospholipid increased and membrane fluidity decreased, with maximum changes attained by 12 weeks. Serum lipoprotein cholesterol/phospholipid also increased, and serum from cholesterol-fed dogs transferred cholesterol to normal red cells. Significant abnormalities of liver function developed in all cholesterol-fed dogs. Hematocrit declined beginning at 6 weeks, with a parallel increase in osmotic fragility. Reticulocytes were elevated in beagles but normal in greyhounds. Red cell morphology resembled acanthocytes or spur cells. All red cell parameters returned to normal within 4 weeks after stopping the diet. These studies demonstrate that a cholestrol-enriched, atherogenic diet causes profound and reversible changes in the lipid composition, membrane fluidity, and morphology of red cells in dogs.[1]

References

  1. Red cell cholesterol enrichment and spur cell anemia in dogs fed a cholesterol-enriched atherogenic diet. Cooper, R.A., Leslie, M.H., Knight, D., Detweiler, D.K. J. Lipid Res. (1980) [Pubmed]
 
WikiGenes - Universities