Serological and genomic characterization of equine rotavirus VP4 proteins identifies three different P serotypes.
A series of viral reassortants was prepared between equine rotaviruses H1 (G5), H2 (G3), and L338 ( G13) and human rotavirus ST3 (G4). All contained the VP4 cognate gene segment 4 from the equine parental virus and the VP7 cognate gene segment 9 from ST3. Using these viruses and antisera prepared to them, it was shown that each of the three equine viruses possessed a serologically distinct VP4 or P serotype with a > or = 16-fold difference in reciprocal cross-neutralization titers. H1 VP4 was closely related to that of porcine virus OSU, i.e., P7. L338 gene 4 was sequenced, and the sequence and serological data indicated that it constituted a novel P serotype L338. P serotype H2 was predominant among our cell culture-adapted equine rotavirus strains, but showed some serological cross-reactivity.[1]References
- Serological and genomic characterization of equine rotavirus VP4 proteins identifies three different P serotypes. Isa, P., Snodgrass, D.R. Virology (1994) [Pubmed]
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