- Loss of heterozygosity in the tuberous sclerosis (TSC2) region of chromosome band 16p13 occurs in sporadic as well as TSC-associated renal angiomyolipomas. Henske, E.P., Neumann, H.P., Scheithauer, B.W., Herbst, E.W., Short, M.P., Kwiatkowski, D.J. Genes Chromosomes Cancer (1995)