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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos.

In C. elegans embryogenesis, the MS blastomere produces predominantly mesodermal cell types, while its sister E generates only endodermal tissue. We show that a maternal gene, pop-1, is essential for the specification of MS fate and that a mutation in pop-1 results in MS adopting an E fate. Previous studies have shown that the maternal gene skn-1 is required for both MS and E development and that skn-1 encodes a transcription factor. We show here that the pop-1 gene encodes a protein with an HMG box similar to the HMG boxes in the vertebrate lymphoid-specific transcriptional regulators TCF-1 and LEF-1. We propose that POP-1 and SKN-1 function together in the early embryo to allow MS-specific differentiation.[1]

References

  1. pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C. elegans embryos. Lin, R., Thompson, S., Priess, J.R. Cell (1995) [Pubmed]
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