The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats.

Peripheral and central injections of recombinant human interleukin-1 beta ( IL-1 beta) have been shown to decrease social exploration and to induce body weight loss in rats. To characterize the receptor mechanisms of these effects, we used as a tool a specific antagonist of the receptors of IL-1, IL-1ra. Intraperitoneal (i.p.) administration of IL-1ra (8 mg/kg) blocked the effect of i.p. injection of IL-1 beta (4 micrograms/rat) on social behaviour but not on body weight. Central administration of IL-1ra (60 micrograms/rat, i.c.v.) abrogated the effects of centrally administered IL-1 beta (30 ng/rat, i.c.v.) on both social behaviour and body weight. Central injection of IL-1ra (4 micrograms/rat, i.c.v.) also attenuated the effects of i.p. administered IL-1 beta (4 micrograms/rat) on social behaviour but not on body weight. These results suggest that the effects of IL-1 beta on social behavior are mediated centrally and that its effect on the loss of body weight involves different receptor mechanisms.[1]

References

  1. Differential effects of IL-1ra on sickness behavior and weight loss induced by IL-1 in rats. Bluthé, R.M., Beaudu, C., Kelley, K.W., Dantzer, R. Brain Res. (1995) [Pubmed]
 
WikiGenes - Universities