- De novo mutation in the mitochondrial ATP synthase subunit 6 gene (T8993G) with rapid segregation resulting in Leigh syndrome in the offspring. Tulinius, M.H., Houshmand, M., Larsson, N.G., Holme, E., Oldfors, A., Holmberg, E., Wahlström, J. Hum. Genet. (1995)