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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice.

DNA damage may mediate birth defects caused by many drugs and environmental chemicals, therefore p53, a tumour suppressor gene that facilitates DNA repair, may be critically embryoprotective. We have studied the effects of the environmental teratogen, benzo[a]pyrene, on pregnant heterozygous p53-deficient mice. Such mice exhibited between 2- to 4-fold higher embryotoxicity and teratogenicity than normal p53-controls. Fetal resorptions reflecting in utero death were genotyped using the polymerase chain reaction and found to be increased 2.6-fold and 3.6-fold respectively with heterozygous and homozygous p53-deficient embryos. These results provide the first direct evidence that p53 may be an important teratological suppressor gene which protects the embryo from DNA-damaging chemicals and developmental oxidative stress.[1]

References

  1. A teratologic suppressor role for p53 in benzo[a]pyrene-treated transgenic p53-deficient mice. Nicol, C.J., Harrison, M.L., Laposa, R.R., Gimelshtein, I.L., Wells, P.G. Nat. Genet. (1995) [Pubmed]
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