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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Control of beta 3-adrenergic receptor gene expression in brown adipocytes in culture.

Brown adipose tissue is a mammalian thermogenic tissue. Its ability to dissipate energy as heat is due to a unique mitochondrial protein, uncoupling protein (UCP). Activation and expression of UCP is under control of the sympathetic nervous system acting through beta -adrenergic receptors (AR). In this study we used Siberian hamster brown adipocytes differentiated in vitro to investigate the expression of the fat specific beta 3-AR. Binding studies using the new labelled beta 3 adrenergic ligand [3H]SB 206606 showed a density of beta 3-AR in brown adipocyte plasma membranes comparable to that measured in vivo. beta 3-AR mRNA expression was very high in mature brown adipocytes and was started to be expressed during differentiation before UCP mRNA. Its half-life was approximately 50 min. Treatment of cells with non-specific beta adrenergic agonists, specific beta 3-adrenergic agonists, and dibutyryl cyclic AMP resulted in a marked down regulation of beta 3-AR mRNA level within several hours.[1]

References

  1. Control of beta 3-adrenergic receptor gene expression in brown adipocytes in culture. Klaus, S., Muzzin, P., Revelli, J.P., Cawthorne, M.A., Giacobino, J.P., Ricquier, D. Mol. Cell. Endocrinol. (1995) [Pubmed]
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