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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning and sequencing of the chicken egg-white avidin- encoding gene and its relationship with the avidin-related genes Avr1-Avr5.

The gene encoding chicken egg-white avidin (Avd) was amplified from chromosomal DNA, cloned and sequenced. The entire coding region of preavidin (pre-Avd) containing four exons was identified by comparing the Avd gene (1119 bp) with the cDNA. It has a high identity percentage (91-95%) with the previously isolated Avd-related genes 1-5 (Avr1-Avr5). Interestingly, comparison of Avd with the Avr genes showed that the introns were better conserved (on average 97%) than the exons (90%). The Avd gene, as well as the cDNA, encodes a Gln residue at position 53 of the mature protein, which is in contrast to the previously determined amino-acid sequence.[1]

References

  1. Cloning and sequencing of the chicken egg-white avidin-encoding gene and its relationship with the avidin-related genes Avr1-Avr5. Wallén, M.J., Laukkanen, M.O., Kulomaa, M.S. Gene (1995) [Pubmed]
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