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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Differential expression of the proto-oncogenes c-abl and c-mos in developing mouse germ cells.

C-abl and c-mos, two proto-oncogenes with unique patterns of expression in gonadal tissues, were examined by in situ hybridization with respect to their expression in the germ line. C-abl transcripts were observed to be most abundant in late round spermatids and elongating spermatids. C-mos transcripts were also expressed in round spermatids, but at much reduced levels compared to the levels of c-abl. C-abl mRNAs were also detected in mouse oocytes which have entered the growth phase. This temporal specificity of accumulation of c-abl transcripts was similar to that observed for c-mos, which also accumulates in growing and fully grown oocytes (follicle stages 4-6). Quantitative evaluation suggested that c-abl mRNA levels in oocytes are at least an order of magnitude lower than those of c-mos transcripts.[1]

References

  1. Differential expression of the proto-oncogenes c-abl and c-mos in developing mouse germ cells. Iwaoki, Y., Matsuda, H., Mutter, G.L., Watrin, F., Wolgemuth, D.J. Exp. Cell Res. (1993) [Pubmed]
 
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