Potentiated necrosis of cultured cortical neurons by neurotrophins.
The effects of neurotrophins on several forms of neuronal degeneration in murine cortical cell cultures were examined. Consistent with other studies, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 all attenuated the apoptotic death induced by serum deprivation or exposure to the calcium channel antagonist nimodipine. Unexpectedly, however, 24-hour pretreatment with these same neurotrophins markedly potentiated the necrotic death induced by exposure to oxygen-glucose deprivation or N-methyl-D-aspartate. Thus, certain neurotrophins may have opposing effects on different types of death in the same neurons.[1]References
- Potentiated necrosis of cultured cortical neurons by neurotrophins. Koh, J.Y., Gwag, B.J., Lobner, D., Choi, D.W. Science (1995) [Pubmed]
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