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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Urogenital manifestations of Wegener granulomatosis.

We report 8 patients with Wegener granulomatosis ( WG) who suffered from symptomatic urogenital involvement including acute urinary retention related to prostatitis, orchitis, ureteral stenosis, bladder pseudotumor, and penile ulceration. Urogenital manifestations occurred as an isolated manifestation of WG in 4 patients, at the onset of the disease in 1 patient, and as the only symptom of relapse in 3. Data used to distinguish specific WG involvement from infection or cyclophosphamide urothelial toxicity are discussed. Four patients needed a surgical procedure consisting of suprapubic cystostomy for acute urinary retention, bilateral ureteral double J stents for bilateral ureteral stenosis, and prostate transurethral resection. Urogenital symptoms promptly resolved with medical therapy. High-dose corticosteroids and immunosuppressive drugs should be used as first-line therapy to avoid unnecessary surgery.[1]

References

  1. Urogenital manifestations of Wegener granulomatosis. Huong, D.L., Papo, T., Piette, J.C., Wechsler, B., Bletry, O., Richard, F., Valcke, J.C., Godeau, P. Medicine (Baltimore) (1995) [Pubmed]
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