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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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cis-splicing and polyadenylation of actin RNA can precede 5' trans-splicing in nematodes.

In nematodes many precursor RNAs undergo both cis-splicing (intron removal) and trans-splicing (spliced leader addition) via molecular mechanisms thought to be very similar. We examined the temporal order of trans- and cis-splicing by analyzing cDNAs of partially processed transcripts from an actin gene of the parasitic nematode, Onchocerca volvulus, which has five short introns. We found that in this model gene system trans-splicing can follow cis-splicing and polyadenylation, and we obtained no evidence for alternative pathways of splicing. This result is in contrast to the tubulin genes of African trypanosomes where trans-splicing precedes polyadenylation (1).[1]

References

  1. cis-splicing and polyadenylation of actin RNA can precede 5' trans-splicing in nematodes. Shiwaku, K., Donelson, J.E. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
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