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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

The analysis of p53 tumor suppressor gene in pineal parenchymal tumors.

p53 gene mutation was examined in 9 pineal parenchymal tumors, 4 pineoblastomas and 5 pineocytomas, by the immunohistochemical and the polymerase chain reaction-mediated single strand conformation polymorphism (PCR-SSCP) analyses. In each case, immunohistochemical analysis revealed no positive staining for p53 protein with either PAb1801 or DO-1 antibody and PCR-SSCP analysis revealed no abnormal migration in exons 5 to 8 of the p53 gene. These findings suggested that p53 gene mutation is rarely related with the tumorigenesis of pineal parenchymal tumors.[1]


  1. The analysis of p53 tumor suppressor gene in pineal parenchymal tumors. Tsumanuma, I., Sato, M., Okazaki, H., Tanaka, R., Washiyama, K., Kawasaki, T., Kumanishi, T. Nōshuyō byōri = Brain tumor pathology. (1995) [Pubmed]
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