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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor.

We have characterized the structure of a mouse bone morphogenetic protein ( BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (> 40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.[1]

References

  1. Genomic organization and chromosomal location of the mouse type I BMP-2/4 receptor. Mishina, Y., Suzuki, A., Gilbert, D.J., Copeland, N.G., Jenkins, N.A., Ueno, N., Behringer, R.R. Biochem. Biophys. Res. Commun. (1995) [Pubmed]
 
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