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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma.

The T-cell receptor (TCR)/CD3 complex is the surface molecule responsible for the highly specific response to foreign antigens, including tumour-associated antigens. and correlations have been observed with disease status. Recently, low amounts of CD3 gamma and CD3 zeta chains in the CD3/TCR complex have been reported in long-term tumour-bearing mice as a possible mechanism for the impaired T-cell responses. In this study we report a B-cell lymphoma in which T-cell CD3 zeta expression correlated with disease activity.[1]

References

  1. Correlation between disease activity and T-cell CD3 zeta chain expression in a B-cell lymphoma. Massaia, M., Attisano, C., Beggiato, E., Bianchi, A., Pileri, A. Br. J. Haematol. (1994) [Pubmed]
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