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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains.

The myb gene family has three members, c-myb, A-myb, and B-myb. A-myb mRNA is mainly expressed in testis and peripheral blood leukocytes. A-Myb can activate transcription from the promoter containing Myb-binding sites in all cells examined. In addition to the two domains (a DNA-binding domain and a transcriptional activation domain), two negative regulatory domains have been identified in A-Myb. These results indicate that A-Myb functions as a transcriptional activator mainly in testis and peripheral blood cells, and the regulatory mechanism of A-Myb activity is similar to that of c-Myb.[1]

References

  1. Human A-myb gene encodes a transcriptional activator containing the negative regulatory domains. Takahashi, T., Nakagoshi, H., Sarai, A., Nomura, N., Yamamoto, T., Ishii, S. FEBS Lett. (1995) [Pubmed]
 
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