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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I.

The human T-cell leukemia virus type I Tax protein trans-activates several cellular genes implicated in T-cell replication and activation. To investigate its leukemogenic potential, Tax was targeted to the mature T-lymphocyte compartment in transgenic mice by using the human granzyme B promoter. These mice developed large granular lymphocytic leukemia, demonstrating that expression of Tax in the lymphocyte compartment is sufficient for the development of leukemia. Furthermore, these observations suggest that human T-cell leukemia virus infection may be involved in the development of large granular lymphocytic leukemia.[1]

References

  1. Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I. Grossman, W.J., Kimata, J.T., Wong, F.H., Zutter, M., Ley, T.J., Ratner, L. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
 
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