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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Pharmacologic treatment of autonomic dysreflexia in the rat.

Autonomic dysreflexic hypertension occurs in up to 80% of spinal cord injury patients with lesions thoracic level 6 or higher. Pharmacologic agents directed at each part of the autonomic dysreflexic circuit were tested for efficacy in a rat model. Guanethidine (15 mg/kg intraperitoneally), alpha-methyl-paratyrosine (20 mg/kg intraperitonally), propranolol (3 mg/kg intraperitonally) and control were each tested on groups of three rats with intrinsic control blood pressure measurements. Results show an increase of 15 +/- 5 mm Hg diastolic pressure in control animals compared with no detectable increase with guanethidine or alpha-methyl-paratyrosine. There was an 11 +/- 2 mm Hg increase in diastolic pressure with propranolol. In conclusion, screening drug trials show that the ganglionic blocking agent, guanethidine, and competitive tyrosine uptake precursor, alpha-methyl-paratyrosine, effectively blocked dysreflexic hypertension, whereas the beta-blocker, propranolol, did not.[1]

References

  1. Pharmacologic treatment of autonomic dysreflexia in the rat. Chiou-Tan, F.Y., Lenz, M.L., Robertson, C.S., Grabois, M. American journal of physical medicine & rehabilitation / Association of Academic Physiatrists. (1994) [Pubmed]
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