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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Randomised trial of prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin.

Biliary stents are liable to clog. We investigated whether a choleretic plus an antibiotic could delay clogging. 20 consecutive patients with a malignant biliary stricture were randomised after endoscopic insertion of a polyethylene stent to receive ursodeoxycholic acid plus norfloxacin (13-15 mg/kg and 400 mg, daily) or conservative treatment. The drug combination was associated with: a longer median patency of first (49 vs 6 weeks) and all stents (38 vs 7 weeks); a prolonged median survival (67 vs 18 weeks); and a shorter mean hospital stay (0.2 vs 1.0 days per week of survival). Thus ursodeoxycholic acid plus norfloxacin may prevent stent clogging.[1]

References

  1. Randomised trial of prevention of biliary stent occlusion by ursodeoxycholic acid plus norfloxacin. Barrioz, T., Ingrand, P., Besson, I., de Ledinghen, V., Silvain, C., Beauchant, M. Lancet (1994) [Pubmed]
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