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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B.

A new series of thirty derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines has been synthesized and the compounds assayed as inhibitors of MAO-A and MAO-B from bovine brain mitochondria. IC50 values for both isoenzymes were determined using tyramine as a common substrate. Structure-activity and selectivity relationships are discussed.[1]

References

  1. Acetylenic and allenic derivatives of 2-(5-methoxy-1-methylindolyl)alkylamines as selective inhibitors of MAO-A and MAO-B. Fernández García, C., Marco, J.L., Fernández-Alvarez, E. J. Neural Transm. Suppl. (1994) [Pubmed]
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