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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle.

Leukemic B cells from a majority of patients with chronic lymphocytic leukemia (CLL) enter the cell cycle upon stimulation in vitro with loxoribine, a potent 7,8-disubstituted guanine ribonucleoside immunostimulant. In the absence of added costimulants, a proportion of these cells become activated and undergo DNA synthesis and mitosis accompanied by a marked increase in expression of an array of cell surface activation antigens. The resultant activated B-CLL cells exhibit greatly enhanced sensitivity to cycle-active cytotoxic drugs. This approach may be of potential value in the therapy of CLL.[1]

References

  1. Loxoribine induces chronic lymphocytic leukemia B cells to traverse the cell cycle. Goodman, M.G., Wormsley, S.B., Spinosa, J.C., Piro, L.D. Blood (1994) [Pubmed]
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