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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Penfluridol and thiothixene. Dosage, plasma levels and changes in psychopathology.

Plasma levels of penfluridol and thiothixene were studied after 4 weeks treatment in a double-blind controlled trial of 47 patients suffering from chronic schizophrenic syndromes. There was found a tenfold variation in plasma levels for penfluridol, and about a twentyfold variation for thiothixene. For penfluridol, a significant correlation between dosage and plasma level and also between dosage and changes in psychopathology as regards factor 5 in the Märtens & Jonsson S scale which comprises the items most characteristic of a schizophrenic syndrome, was found. For thiothixene, a significant correlation between plasma levels and changes in factor 5 was found. A gas-chromatographic method for penfluridol is also described.[1]

References

  1. Penfluridol and thiothixene. Dosage, plasma levels and changes in psychopathology. Jacobsson, L., von Knorring, L., Mattsson, B., Mjörndal, T., Oreland, L., Perris, C., Rapp, W., Edenius, B., Kettner, B., Magnusson, K.E., Villemoes, P. International pharmacopsychiatry. (1976) [Pubmed]
 
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