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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat.

Repeated treatment with dl-pentazocine (5-10 mg/kg i.p.), but not d-methamphetamine (4.8 mg/kg i.p.), twice daily for 8 days diminished the specific [3H]1,3-di-o-tolylguanidine (DTG) binding to the haloperidol-sensitive sigma sites in rat striatum and hippocampus. Either drug failed to cause any changes in the binding to the hypothalamus and prefrontal cortex. The pentazocine-induced diminution in the striatum was accompanied by a decrease in the density with an increase in the affinity of the [3H]DTG binding. These data suggest that repetitive use of dl-pentazocine may influence the regulation systems of the sigma site in specific brain regions.[1]

References

  1. Differential effects of repeated dl-pentazocine treatment on sigma binding sites in discrete brain areas of the rat. Shirayama, Y., Nishikawa, T., Takahashi, K. Neurosci. Lett. (1994) [Pubmed]
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