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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages.

The transcription factor PU.1 is a hematopoietic-specific member of the ets family. Mice carrying a mutation in the PU.1 locus were generated by gene targeting. Homozygous mutant embryos died at a late gestational stage. Mutant embryos produced normal numbers of megakaryocytes and erythroid progenitors, but some showed an impairment of erythroblast maturation. An invariant consequence of the mutation was a multilineage defect in the generation of progenitors for B and T lymphocytes, monocytes, and granulocytes. Thus, the developmental programs of lymphoid and myeloid lineages require a common genetic function likely acting at the level of a multipotential progenitor.[1]

References

  1. Requirement of transcription factor PU.1 in the development of multiple hematopoietic lineages. Scott, E.W., Simon, M.C., Anastasi, J., Singh, H. Science (1994) [Pubmed]
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