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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Reversal of inherent multidrug-resistance in primary human renal cell carcinoma cell cultures by S 9788.

In a panel of 14 primary cultures of human renal cell carcinomas the reversal of inherent multidrug-resistance by S 9788, a new triazinoaminopiperidine derivative, was analysed. In combination with doxorubicin S 9788 revealed an evident reversal of multidrug resistance in 12 cell cultures. Two cell cultures remained unaffected. An association between reversal and P-glycoprotein (P-170) expression suggests that S 9788 exerts its activity through P-glycoprotein.[1]

References

  1. Reversal of inherent multidrug-resistance in primary human renal cell carcinoma cell cultures by S 9788. Efferth, T., Dunn, T.A., Berlion, M., Langenbahn, H., Pommerenke, E.W., Volm, M. Anticancer Res. (1993) [Pubmed]
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