Evidence for at least three transcribed BoLA class I loci.
Serological data identify a single major histocompatibility complex ( MHC) class I locus in cattle. Molecular data, however, demonstrate the presence of at least two cattle MHC (BoLA) class I loci. To investigate the number of transcribed BoLA class I genes, we amplified cattle cDNA by using a single MHC class I-specific primer that hybridized to a conserved region of exon 4 and a non-specific 3' primer. Six BoLA class I cDNAs have been cloned and sequenced from a Bos taurus bull heterozygous for BoLA class I serological antigens, demonstrating the presence of a minimum of three loci. Sequence comparisons suggested that one of these cDNAs may be an unexpressed allele or the product of a nonclassical locus.[1]References
- Evidence for at least three transcribed BoLA class I loci. Garber, T.L., Hughes, A.L., Watkins, D.I., Templeton, J.W. Immunogenetics (1994) [Pubmed]
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