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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Comparative fractal analysis of cultured glia derived from optic nerve and brain demonstrate different rates of morphological differentiation.

O-2A progenitor cells derived from neonatal rat cerebral hemispheres or optic nerves, were induced to differentiate in culture into either oligodendrocytes or type 2 astrocytes. The fractal dimensions, a measure of morphological complexity, of the differentiating glial cells were measured over time. Analysis of the changes in fractal dimension ( D) with respect to time revealed specific rates of growth for each glial phenotype and a specific final D. The time course of these changes is well fit by a simple mathematical model. While brain-derived oligodendrocytes matured faster than the astrocytes, they ultimately attained comparable levels of complexity, with similar maximum fractal dimensions. Oligodendrocytes from nerve also matured faster than nerve derived astrocytes, in contrast, however, they attained a greater morphological complexity than nerve astrocytes. While the brain-derived oligodendrocytes showed a faster rate of maturation than their optic nerve counterparts, astrocytes from both regions had similar rates of morphological differentiation. Self-similarity, a defining property of fractal objects was investigated, by determining the fractal dimension of cells over a range of magnifications. The calculated fractal dimension remained constant over a 10-fold range in optical magnification, illustrating that cultured glial cells exhibit this important characteristic of fractal objects. In addition, we analyzed the branching patterns of glial processes by the Sholl method and found that the results were not as interpretable or meaningful as those of fractal analysis.[1]

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