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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar.

OBJECTIVE. The relationship between rheumatoid factor positive (RF+) and rheumatoid factor negative (RF-) rheumatoid arthritis (RA) is controversial. We sought to determine whether the HLA genes conferring susceptibility for erosive RF+RA are also prevalent in patients with erosive RF-RA. METHODS. DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA. RESULTS. Thirteen of 16 (81%) RF-RA patients had the HLA susceptibility genes DRB1 *0401, *0404, or *0101, which are associated with RF+RA, as compared to 46% of normal controls (p = 0.017). By contrast, no associations with HLA-DQB1 and HLA-DPB1 alleles were apparent. CONCLUSION. Specific HLA susceptibility alleles are prevalent in patients with erosive RA, regardless of RF status, suggesting a similar immunogenetic basis for RA in these patients.[1]

References

  1. Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar. Vehe, R.K., Nepom, G.T., Wilske, K.R., Stage, D., Begovich, A.B., Nepom, B.S. J. Rheumatol. (1994) [Pubmed]
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