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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives.

Site-specific DNA cleavage in the presence of Cu(II) complexes of podophyllotoxin derivatives was investigated with a modified Sanger sequencing method. Cu(II) complexes of 4'-demethylepipodophyllotoxin (DEPD) and syringic acid (SA) cleaved M13mp18 single-strand DNA site-specifically at both cytosine ( C) and guanine ( G) positions in the GC rich regions and C position, respectively, at pH 7. 8. The apparent binding constants of calf thymus DNA-Cu(II) complexes estimated by the differential UV-absorption spectra revealed that both Cu(II)-VP-16 and -DEPD complexes bind to DNA more strongly than does the Cu(II)-SA complex.[1]

References

  1. Site-specific DNA cleavage by Cu(II) complexes of podophyllotoxin derivatives. Yamashita, A., Tawa, R., Imakura, Y., Lee, K.H., Sakurai, H. Biochem. Pharmacol. (1994) [Pubmed]
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