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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast.

We have devised a complementation assay in yeast to clone mammalian transcriptional activators and have used it to identify a human basic leucine-zipper transcription factor that we have designated Nrf1 for NF-E2-related factor 1. Nrf1 potentially encodes a 742-aa protein and displays marked homology to the mouse and human NF-E2 transcription factors. Nrf1 activates transcription via NF-E2 binding sites in yeast cells. The ubiquitous expression pattern of Nrf1 and the range of promoters containing the NF-E2 binding motif suggest that this gene may play a role in the regulation of heme synthesis and ferritin genes.[1]

References

  1. Cloning of Nrf1, an NF-E2-related transcription factor, by genetic selection in yeast. Chan, J.Y., Han, X.L., Kan, Y.W. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
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