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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Osteoconductive properties of methylpyrrolidinone chitosan in an animal model.

Bone defects were surgically produced in the tibiae of rabbits and medicated with freeze-dried methylpyrrolidinone chitosan. Histological observations 60 d after surgery showed a considerable presence of neoformed bone tissue, as opposed to controls, originating from the pre-existing bone as well as from the periosteum. The cationic nature and the chelating ability of the methylpyrrolidinone chitosan apparently favoured mineralization. Endosteal-periosteal and bone marrow osteoblast-like precursors, stimulated by growth factors entrapped in the coagulum-polysaccharide mixture, gave rise to intramembranous bone formation. The ultrastructural examination evidenced that bone osteoid was followed by mineralization of the tissue.[1]

References

  1. Osteoconductive properties of methylpyrrolidinone chitosan in an animal model. Muzzarelli, R.A., Zucchini, C., Ilari, P., Pugnaloni, A., Mattioli Belmonte, M., Biagini, G., Castaldini, C. Biomaterials (1993) [Pubmed]
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