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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Recombinase activating gene expression in thymic subpopulations. A transitional cell type has lost RAG-2 but not RAG-1.

We have used a highly sensitive Northern blot probing technique to examine RAG-1 and RAG-2 mRNA expression in unmanipulated murine thymocytes of various developmental phenotypes sorted by flow cytometry. We have found that neither RAG-1 nor RAG-2 are down-regulated until thymocytes reach the TCRhi stage. TCRhi, CD8+CD4+ cells have lost RAG-2 mRNA but continue to express significant levels of RAG-1 mRNA, providing molecular evidence that this cell type is transitional between the TCRlo, CD4+CD8+ and the TCRhi, CD4+CD8-, or CD4-CD8+ phenotypes.[1]

References

  1. Recombinase activating gene expression in thymic subpopulations. A transitional cell type has lost RAG-2 but not RAG-1. Campbell, J.J., Hashimoto, Y. J. Immunol. (1993) [Pubmed]
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