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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Development of an antibody-based amperometric biosensor to study the reaction of 7-hydroxycoumarin with its specific antibody.

An amperometric biosensor, based on an anti-7-hydroxycoumarin (7-OH-coumarin) antibody immobilized at the surface of a glassy carbon electrode, and contained behind a cellulose dialysis membrane, is described. The electrochemical behaviour of this metabolite at the bare glassy carbon electrode was found to be well defined by using differential-pulse voltammetry, and a 90% decrease in peak height was observed on binding of the antibody to the antigen, which occurs at the electroactive site of 7-OH-coumarin. The kinetics of the antibody-antigen reaction was investigated and a first-order reaction was observed with k = 0.0329 mA min-1. This system provides a novel method for studying antibody specificity and the kinetics of such antibody-antigen interactions.[1]

References

  1. Development of an antibody-based amperometric biosensor to study the reaction of 7-hydroxycoumarin with its specific antibody. Dempsey, E., O'Sullivan, C., Smyth, M.R., Egan, D., O'Kennedy, R., Wang, J. The Analyst. (1993) [Pubmed]
 
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