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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Aberrant splicing of rat steroid 17 alpha-hydroxylase transcripts.

Polymerase chain reaction amplification of the cDNA encoding steroid 17 alpha-hydroxylase (P450c17) demonstrated very low levels of this transcript and a shorter variant of still lower abundance in rat adrenals and brain. Sequence analysis of the two amplified products revealed that the shorter variant resulted from a deletion of the second exon which does not maintain the open reading frame, suggesting that faulty splicing gave rise to this minor species.[1]

References

  1. Aberrant splicing of rat steroid 17 alpha-hydroxylase transcripts. Sanne, J.L., Krueger, K.E. Gene (1995) [Pubmed]
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