- The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., Russo, T. J. Biol. Chem. (1995)