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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Antioxidative role of ocular melanin pigment in the model of lens induced uveitis.

Ocular melanin pigment has antioxidant effect against excess of dispersed light. To investigate whether it has a similar effect in ocular inflammations, we used albino and pigmented guinea pigs and measured retinal glutathione peroxidase activities and lipid peroxide levels (expressed as thiobarbituric acid reactive substances) in a model of lens induced uveitis. Although the increase in the levels of the retinal lipid peroxides were higher in the albino group (204%, p < 0.05), the decrease in the activities of glutathione peroxidase were higher in pigmented guinea pigs (26%, p < 0.005). The results of the study suggest that pigmentless animals are more sensitive to the ocular inflammations, and ocular melanin pigment may act as an endojen antioxidant in lens induced uveitis.[1]

References

  1. Antioxidative role of ocular melanin pigment in the model of lens induced uveitis. Bilgihan, A., Bilgihan, M.K., Akata, R.F., Aricioğlu, A., Hasanreisoğlu, B. Free Radic. Biol. Med. (1995) [Pubmed]
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