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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice.

CD30 is found on Reed-Sternberg cells of Hodgkin's disease and on a variety of non-Hodgkin's lymphoma cells and is up-regulated on cells after Epstein-Barr virus, human T cell leukemia virus, and HIV infections. We report here that the thymus in CD30-deficient mice contains elevated numbers of thymocytes. Activation-induced death of thymocytes after CD3 cross-linking is impaired both in vitro and in vivo. Breeding the CD30 mutation separately into alpha beta TCR-or gamma delta TCR-transgenic mice revealed a gross defect in negative but not positive selection. Thus, like TNF-receptors and Fas/Apo-1, the CD30 receptor is involved in cell death signaling. It is also an important coreceptor that participates in thymic deletion.[1]

References

  1. Impaired negative selection of T cells in Hodgkin's disease antigen CD30-deficient mice. Amakawa, R., Hakem, A., Kundig, T.M., Matsuyama, T., Simard, J.J., Timms, E., Wakeham, A., Mittruecker, H.W., Griesser, H., Takimoto, H., Schmits, R., Shahinian, A., Ohashi, P., Penninger, J.M., Mak, T.W. Cell (1996) [Pubmed]
 
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