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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi.

The antimicrobial mechanism of totarol was studied using Pseudomonas aeruginosa IFO 3080. This diterpene inhibited oxygen consumption and respiratory-driven proton translocation in whole cells, and oxidation of NADH in membrane preparation. NADH-cytochrome c reductase was inhibited by totarol while cytochrome c oxidase was not. NADH-DPIP reductase and NADH-CoQ reductase were also inhibited. The site of respiratory inhibition of totarol was thought to be near CoQ in the bacterial electron transport chain.[1]

References

  1. Mode of antibacterial action of totarol, a diterpene from Podocarpus nagi. Haraguchi, H., Oike, S., Muroi, H., Kubo, I. Planta Med. (1996) [Pubmed]
 
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