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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists.

The involvement of spinal cord serotonergic influences in the development of autotomy, a proposed behavioural model of denervation pain, was studied in rats subjected to sciatic and saphenous nerve transection 5 min after intrathecal injection of 100 or 200 mu g of several serotonergic receptor subtype agonists. Injection of 8-OH-DPAT, m-CPP, 2-m-5-HT and a low dose of 5-HT, significantly shifted one or more of the parameters describing autotomy to less intense behaviour. In contrast, the injection of CGS-12066B and DOI intensified autotomy. These results suggest both a modulatory role for spinal cord serotonin in the events occurring shortly after neurectomy and new therapeutic approaches for the prevention of certain pain syndromes, such as phantom limb pain.[1]

References

  1. Modulation of neuropathic pain in rats by intrathecally injected serotonergic agonists. Sanchez, A., Niedbala, B., Feria, M. Neuroreport (1995) [Pubmed]
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