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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter.

Inorganic phosphate (Pi) induced an inward current (IP) in Xenopus oocytes expressing the human renal Na+/Pi cotransporter NaPi-3. At 100mM Na+, Pi-transport was independent of the holding potential and resulted in an apparent Km of 0.08 mM; lowering the Na+ concentration to 50 mM resulted in an increase of the apparent Km to 0.22 mM at -50 mV and to 0.31 mM at -90 mV. In contrast, the apparent Km for Na+ was not significantly influenced by the holding potential. A decrease of the pH from 7.8 to 6.8 resulted in a decrease of IP at 50 mM Na+, but not at 150 mM Na+. Arsenate induced inward currents through NaPi-3 and decreased the apparent Km in measurements of IP. Phosphonoformic acid itself induced no currents, but inhibited Pi-induced currents with an apparent Ki of 3.6 mM. In summary, NaPi-3 displays characteristic Na+/Pi cotransporter properties with relevant interactions with arsenate (transport substrate) and phosphonoformic acid (inhibitor). Monovalent and divalent Pi both appear to be transported by NaPi-3.[1]

References

  1. Properties of electrogenic Pi transport by a human renal brush border Na+/Pi transporter. Busch, A.E., Wagner, C.A., Schuster, A., Waldegger, S., Biber, J., Murer, H., Lang, F. J. Am. Soc. Nephrol. (1995) [Pubmed]
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