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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cell proliferation in human cutaneous squamous cell carcinoma.

Squamous cell carcinoma ( SCC) of the skin, a fairly slow-growing locally invasive tumor that occasionally matastasizes, was studied in 12 patients in vivo with the use of intralesional tritiated thymidine as a marker for cell proliferation kinetics. Analysis of the cell cycle of the germinative population revealed that the duration of S-phase was 12.5 hours; G1-phase, 28.8 hours; mitotic period (M-phase), 2 hours; G-pahse, 6.9 hours; and the total germinative cell cycle, 50.2 hours. The application of cell kinetics to programming chemotherapy for skin cancer with phase-specific cytotoxins was discussed.[1]

References

  1. Cell proliferation in human cutaneous squamous cell carcinoma. Friedland, A.M., Weinstein, G.D. J. Natl. Cancer Inst. (1977) [Pubmed]
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