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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Increased hepatic copper concentration in Indian childhood cirrhosis.

19 Indian children with liver disease were studied. 5 in whom a clinical and histological diagnosis of Indian Childhood Cirrhosis was made had massive orcein-staining deposits in liver cells. The hepatic copper content in these 5 cases was strikingly high (1389 microgram/g dry tissue, range 1045--2303) the normal range being 15--55 microgram/g. Of the other 14 cases, only 2 had hepatic copper levels above normal (170 and 262 microgram/g.) This high hepatic copper concentration may be caused by excessive copper ingestion or an abnormality of copper metabolism.[1]

References

  1. Increased hepatic copper concentration in Indian childhood cirrhosis. Tanner, M.S., Portmann, B., Mowat, A.P., Williams, R., Pandit, A.N., Mills, C.F., Bremner, I. Lancet (1979) [Pubmed]
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