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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Cyproheptadine treatment in neuroleptic-induced akathisia.

BACKGROUND: Cyproheptadine, an antiserotonergic agent, was used to treat neuroleptic-induced akathisia. METHOD: In an open clinical trial 17 neuroleptic-treated patients with akathisia were administered cyproheptadine (16 mg/day) over 4 days. Assessment of akathisia, psychosis and depression were monitored by BAS, BPRS and HAM-D. RESULTS: All subjects showed improvement in the severity of akathisia, which in the majority (15/17) was of a marked degree. There was no aggravation of psychosis or depression. Symptoms of akathisia returned when cyproheptadine was discontinued. CONCLUSIONS: Cyproheptadine may be useful in neuroleptic-induced akathisia.[1]

References

  1. Cyproheptadine treatment in neuroleptic-induced akathisia. Weiss, D., Aizenberg, D., Hermesh, H., Zemishlany, Z., Munitz, H., Radwan, M., Weizman, A. The British journal of psychiatry : the journal of mental science. (1995) [Pubmed]
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