- Failure of pretreatment with intravenous folic acid to alter the cumulative hematologic toxicity of lometrexol. Muggia, F.M., Synold, T.W., Newman, E.M., Jeffers, S., Leichman, L.P., Doroshow, J.H., Johnson, K., Groshen, S. J. Natl. Cancer Inst. (1996)