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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Primary structure of bovine adenosine deaminase.

Derivatized bovine adenosine deaminase is used in enzyme replacement therapy and as an adjunct to gene therapy against severe combined immunodeficiency syndrome. Although a gene sequence is known for human adenosine deaminase, the structure of the bovine enzyme has not been characterized. Structure studies using mass spectrometry are reported here that evaluate sequence, processing, post-translational modifications and the extent of homology between the human protein and its therapeutic surrogate.[1]


  1. Primary structure of bovine adenosine deaminase. Kelly, M.A., Vestling, M.M., Murphy, C.M., Hua, S., Sumpter, T., Fenselau, C. Journal of pharmaceutical and biomedical analysis. (1996) [Pubmed]
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