The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Breath-by-breath measurements for the analysis of exogenous glucose oxidation during intense endurance exercise using [13C]-isotopes.

Up to now only the analysis of 13CO2 in separate breath-gas samples after administration of [13C]-labelled carbohydrates with intervals of several minutes in between has been available for analyses of the exogenous glucose oxidation during exercise. Our studies show the use of rapid respiratory mass spectrometry for breath-by-breath analysis to determine exogenous glucose utilization. Six male triathletes performed two exercise tests of 100-min duration each on a cycle ergometer. In both tests 5 min after the beginning of cycling glucose was administered. In test 1 30 g natural glucose was given, in test 2 a mixture of 1.5 g [13C1]-glucose and 28.5 g natural glucose. The work rate was regulated to keep constant 90% of the VO2 at the VO2 levelling off (VO2max) measured in a short ramp test. The resulting work rate was at 260.2 +/- 9.5 watts in test 1 and at 276.3 +/- 12.1 watts in test 2. Respiration gases and the end-tidal concentrations of 12CO2 (12C) and 13CO2 (13C) were calculated breath-by-breath online. The course of the ratio [13C/12C] reflects the course of exogenous glucose utilization. Onset of utilization was 10.5 +/- 5.5 min following oral administration. Maximum utilization was attained at 53.1 +/- 9.8 min with a maximal rate of oxidation of 0.36 +/- 0.05 g/min. The beginning of the energy supply of exogenous glucose could be determined quite soon after oral administration.[1]

References

  1. Breath-by-breath measurements for the analysis of exogenous glucose oxidation during intense endurance exercise using [13C]-isotopes. Röcker, K., Krieg, B., Niess, A., Dickhuth, H.H. International journal of sports medicine. (1996) [Pubmed]
 
WikiGenes - Universities