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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Stimulation by retinoids of the natriuretic peptide system of osteoblastic MC3T3-E1 cells.

The effects were examined of treatment with retinoids of osteoblastic MC3T3-E1 cells on the natriuretic peptide system that promotes the differentiation of osteoblastic cells. Northern blot analysis revealed high levels of mRNA for the retinoid X receptor beta (RXR beta) and moderate levels of mRNAs for retinoic acid receptors alpha (RAR alpha) and gamma (RAR gamma). Exposure of MC3T3-E1 cells to 1 microM retinoid caused increases in the levels of C-type natriuretic peptide (CNP) and natriuretic peptide receptor-C (NPR-C). The activity of natriuretic peptide receptor-B (NPR-B) was unchanged after the addition of retinoid to the culture system. These results suggest that retinoids might influence the metabolism of osteoblastic cells through regulation of the natriuretic peptide system.[1]

References

  1. Stimulation by retinoids of the natriuretic peptide system of osteoblastic MC3T3-E1 cells. Inoue, A., Otsuka, E., Hiruma, Y., Hirose, S., Furuya, M., Tanaka, S., Hagiwara, H. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
 
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