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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B.

A transcription unit was identified in the 43E polytene band region of the second chromosome of Drosophila melanogaster (Dm) whose putative translation product has 85% amino acid (aa) identity with the B subunit of the calcineurin protein (CnB) from humans. Unlike the previously described intronless Dm CnB gene homologue, which is located within the 4F band region of the X chromosome, the coding region of this second CnB is found to be interrupted by three introns. Conceptual translation of both Dm CnB genes predict proteins of identical size that are 98% identical in aa sequence. Northern blot analyses indicate that Dm pupae and adults express two different CnB-encoding transcripts that are differentially regulated.[1]

References

  1. Drosophila melanogaster contains both X-linked and autosomal homologues of the gene encoding calcineurin B. Warren, W.D., Phillips, A.M., Howells, A.J. Gene (1996) [Pubmed]
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