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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Effects of 0-/-B-hydroxyethyl/rutoside on platelet function and thrombus formation in rat mesenteric vessels.

0-/-B-hydroxyethyl/rutoside has been investigated for its effect on laser-induced thrombus formation in rat mesenteric venules and arterioles. The in vitro effect of this agent on platelet adhesion to bovine subendothelial extracellular matrix ( ECM) and glass, on spreading and on platelet aggregation induced by ADP, collagen and epinephrine have also been studied. The animal investigations of 0-/-B-hydroxyethyl/rutoside showed an antithrombotic effect in doses between 5 and 50 mg/kg after i.v. injection. This effect was similar for both arterioles and venules damaged. After i.v. injection of minimum effective doses of 0-/-B-hydroxyethyl/rutoside, the antithrombotic effect lasted longer than 6 hrs but less than 12 hrs. In vitro, 0-/-B-hydroxyethyl/rutoside significantly inhibited platelet adhesion to bovine ECM in concentrations of 20 micrograms/ml PRP, and with 30 micrograms/ml the PRP adhesion to glass and spreading were inhibited. Epinephrine and ADP induced aggregation was inhibited in concentrations higher than 30 micrograms/ml PRP.[1]

References

  1. Effects of 0-/-B-hydroxyethyl/rutoside on platelet function and thrombus formation in rat mesenteric vessels. Krupiński, K., Breddin, H.K., Giedrojć, J., Bodzenta-Lukaszyk, A., Bielawiec, M. Materia medica Polona. Polish journal of medicine and pharmacy. (1995) [Pubmed]
 
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